Document Details
Document Type |
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Article In Journal |
Document Title |
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Pregabalin: preliminary experience in intractable childhood epilepsy. استخدام علاج البريقابالين لعلاج صرع الأطفال المستعصى |
Document Language |
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English |
Abstract |
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Pregabalin is a new antiepileptic drug that acts at presynaptic calcium channels, modulating neurotransmitter release. We report our experience in treating consecutive children with severe drug resistant epilepsy in a prospective, open label, add on trial. Nineteen children (63% males) aged 4-15 years (mean 9.7, SD 2.9) were included. Most children (74%) had daily seizures that failed multiple drugs (mean 5). The epilepsy was symptomatic in 58%, and 74% had associated cognitive deficits. The seizures were mixed in 9 (47%) and 4 (21%) had Lennox Gastaut syndrome. Pregabalin was maintained at 150-300 mg/day. On pregabalin, 1 (6%) child became seizure free and 7 (37%) had >50% seizure reduction. The percentage of children with daily seizure was reduced from 74% before pregabalin to 37% afterward (p <0.002). Side effects were noted in 6 (32%) with somnolence, weight gain, dizziness, or behavioral change. The drug had to be withdrawn in 5 (26%) children for of lack of efficacy and in 2 (11%) for worsening of myoclonic epilepsy. We conclude that pregabalin is a useful addition in the treatment of refractory childhood epilepsy. The drug should be used with caution in myoclonic epilepsy. Controlled studies are needed to establish long term efficacy and tolerability. |
ISSN |
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0930-2794 |
Journal Name |
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Pediatric Neurology |
Volume |
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5 |
Issue Number |
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40 |
Publishing Year |
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2009 AH
2009 AD |
Article Type |
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Article |
Added Date |
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Wednesday, March 10, 2010 |
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Researchers
محمد جان | jan, Mohammed | Researcher | Doctorate | |
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