تفاصيل الوثيقة
نوع الوثيقة |
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مقال في مجلة دورية |
عنوان الوثيقة |
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A lipidomic and metabolomic serum signature from nonhuman primates exposed to ionizing radiation A lipidomic and metabolomic serum signature from nonhuman primates exposed to ionizing radiation |
لغة الوثيقة |
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الانجليزية |
المستخلص |
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Introduction Due to dangers associated with potential
accidents from nuclear energy and terrorist threats, there is
a need for high-throughput biodosimetry to rapidly assess
individual doses of radiation exposure. Lipidomics and
metabolomics are becoming common tools for determining
global signatures after disease or other physical insult and
provide a ‘‘snapshot’’ of potential cellular damage.
Objectives The current study assesses changes in the
nonhuman primate (NHP) serum lipidome and metabolome
7 days following exposure to ionizing radiation (IR).
Methods Serum sample lipids and metabolites were
extracted using a biphasic liquid–liquid extraction and
analyzed by ultra performance liquid chromatography
quadrupole time-of-flight mass spectrometry. Global radiation
signatures were acquired in data-independent mode. |
ردمد |
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1573-3882 |
اسم الدورية |
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Metabolomics |
المجلد |
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12 |
العدد |
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5 |
سنة النشر |
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1437 هـ
2016 م |
نوع المقالة |
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مقالة علمية |
تاريخ الاضافة على الموقع |
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Thursday, July 20, 2017 |
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الباحثون
Evan L. Pannkuk | Pannkuk, Evan L. | باحث | دكتوراه | |
Evagelia C. Laiakis | Laiakis, Evagelia C. | باحث | دكتوراه | |
Tytus D. Mak | Mak, Tytus D. | باحث | دكتوراه | |
Giuseppe Astarita | Astarita, Giuseppe | باحث | دكتوراه | |
Simon Authier | Authier, Simon | باحث | دكتوراه | |
Karen Wong | Wong, Karen | باحث | دكتوراه | |
Albert J. Fornace Jr | Fornace Jr, Albert J. | باحث | دكتوراه | |
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